Application of over-sampling nano-sensitive optical coherence tomography for monitoring corneal internal structural changes in corneal cross-linking

Yi Zhou; Sergey Alexandrov; Andrew Nolan; Rajib Dey; Nandan Das; Kai Neuhaus; Martin Leahy

doi:10.1117/12.2547317

21 February 2020 Application of over-sampling nano-sensitive optical coherence tomography for monitoring corneal internal structural changes in corneal cross-linking

Yi Zhou, Sergey Alexandrov, Andrew Nolan, Rajib Dey, Nandan Das, Kai Neuhaus, Martin Leahy

Author Affiliations +

Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 112282M (2020) https://doi.org/10.1117/12.2547317
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Corneal cross-linking (CXL) has grown from an interesting concept to a practical clinical treatment for corneal ectatic disease globally in the past three decades. In both understanding the principle of how CXL proceeds and monitoring the clinical procedure, detection of structural changes during cornea CXL plays a significant role. This paper demonstrates a novel over-sampling nano-sensitive optical coherence tomography (osnsOCT) method, which is potential to detect nanoscale structural changes in various tissues, to simultaneously measure the structural variations during the corneal CXL treatment.

Citation Download Citation

Yi Zhou, Sergey Alexandrov, Andrew Nolan, Rajib Dey, Nandan Das, Kai Neuhaus, and Martin Leahy "Application of over-sampling nano-sensitive optical coherence tomography for monitoring corneal internal structural changes in corneal cross-linking", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112282M (21 February 2020); https://doi.org/10.1117/12.2547317

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