Quantitative measurements of intraocular structures including subretinal microinjection bleb volumes using intraoperative optical coherence tomography (Conference Presentation)

Jianwei D. Li; William Raynor; Ananth Sastry M.D.; Al-Hafeez Dhalla; Cynthia Toth M.D.; Christian Viehland; Lejla Vajzovic M.D.; Joseph A. Izatt

doi:10.1117/12.2546504

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9 March 2020 Quantitative measurements of intraocular structures including subretinal microinjection bleb volumes using intraoperative optical coherence tomography (Conference Presentation)

Jianwei D. Li, William Raynor, Ananth Sastry M.D., Al-Hafeez Dhalla, Cynthia Toth M.D., Christian Viehland, Lejla Vajzovic M.D., Joseph A. Izatt

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Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 112280H (2020) https://doi.org/10.1117/12.2546504
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Microscope-integrated optical coherence tomography (MIOCT) systems allow for 4D visualization of thin, semi-transparent structures during ophthalmic microsurgery. While these visualizations have greatly increased the information available to surgeons, new surgical techniques, such as subretinal injections of gene therapies, would benefit from quantitative measurements of structures imaged using OCT. Calibration of true scan dimensions in OCT is complicated by inter-patient ocular variability as well as poor control of scanner-patient alignment. We introduce novel measurement techniques for calibration and de-warping of OCT imagery which allows for accurate measurement of intraocular structures including subretinal microinjection bleb volumes in the ocular posterior segment.

Conference Presentation

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Jianwei D. Li, William Raynor, Ananth Sastry M.D., Al-Hafeez Dhalla, Cynthia Toth M.D., Christian Viehland, Lejla Vajzovic M.D., and Joseph A. Izatt "Quantitative measurements of intraocular structures including subretinal microinjection bleb volumes using intraoperative optical coherence tomography (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280H (9 March 2020); https://doi.org/10.1117/12.2546504

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