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9 March 2020 Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)
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Abstract
We demonstrate a contact-lens (CL) based mobile sensing system which can be used to measure protein levels in human tear. By using a cost-effective mobile-phone-based well-plate reader and a fluorescent assay, we quantify lysozyme nonspecifically bound to CLs. We monitored the lysozyme levels of 9 healthy volunteers to establish individual baselines, and then compared these measurements to participants who had been diagnosed with Dry Eye Disease (N=6), observing a statistically significant difference in their means. Due to its non-invasive and simple operation, this method could be used for tear-based sensing and health monitoring applications in point-of-care settings and at home.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Zachary S. Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, and Aydogan Ozcan "Contact lens-based lysozyme detection in tear using a mobile and cost-effective sensor (Conference Presentation)", Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 112300R (9 March 2020); https://doi.org/10.1117/12.2546656
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