Hybrid organosilicon/polyol phantoms for applications in biophotonics and beyond

Lucia Cavigli; Sonia Centi; Claudia Borri; Giada Magni; Andrea Barucci; Marina Mazzoni; Roberto Carpi; Roberto Incalcaterra; Giacomo Belli; Roberto Pini; Fulvio Ratto

doi:10.1117/12.2545002

17 February 2020 Hybrid organosilicon/polyol phantoms for applications in biophotonics and beyond

Lucia Cavigli, Sonia Centi, Claudia Borri, Giada Magni, Andrea Barucci, Marina Mazzoni, Roberto Carpi, Roberto Incalcaterra, Giacomo Belli, Roberto Pini, Fulvio Ratto

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Proceedings Volume 11231, Design and Quality for Biomedical Technologies XIII; 112310S (2020) https://doi.org/10.1117/12.2545002
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Recent advances of medical technologies are demanding a new generation of phantoms that may encode the biophysical features needed for their assessment. Here, we propose hybrid materials based on emulsions of polydimethylsiloxane with glycerol or aqueous polyvinyl alcohol as a versatile platform for phantoms for applications such as optical, acoustic, magnetic resonance or X-ray imaging. These materials display intrinsic optical scattering, retain the acoustic features of polydimethylsiloxane, enable the inclusion of a broad taxonomy of hydrophobic and hydrophilic dyes of interest for photoacoustic imaging, may be suitable to simulate the cellularity of organs due to their peculiar microstructure, and, thanks to the possibility to include aqueous solutions of metabolites, may be of interest for magnetic resonance imaging and computed tomography

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Lucia Cavigli, Sonia Centi, Claudia Borri, Giada Magni, Andrea Barucci, Marina Mazzoni, Roberto Carpi, Roberto Incalcaterra, Giacomo Belli, Roberto Pini, and Fulvio Ratto "Hybrid organosilicon/polyol phantoms for applications in biophotonics and beyond", Proc. SPIE 11231, Design and Quality for Biomedical Technologies XIII, 112310S (17 February 2020); https://doi.org/10.1117/12.2545002

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KEYWORDS

Magnetic resonance imaging

Acoustics

Biomedical optics

Reflectors

Photoacoustic spectroscopy

Scanners

Scattering

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