Optical access to the brain through a transparent cranial implant

Mildred S. Cano-Velázquez; Nami Davoodzadeh; David Halaney; Carrie R. Jonak; Devin K. Binder; Juan Hernández-Cordero; Guillermo Aguilar

doi:10.1117/12.2541042

21 February 2020 Optical access to the brain through a transparent cranial implant

Mildred S. Cano-Velázquez, Nami Davoodzadeh, David Halaney, Carrie R. Jonak, Devin K. Binder, Juan Hernández-Cordero, Guillermo Aguilar

Author Affiliations +

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112341A (2020) https://doi.org/10.1117/12.2541042
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Laser-based diagnostics and therapeutics show promise for many neurological disorders. However, the poor transparency of the cranial bone limits the spatial resolution and interaction depth that can be achieved with these technologies. We have recently demonstrated a new method to address this challenge in biomedical research through the use of a novel transparent cranial implant made from nanocrystalline yttria-stabilized zirconia (ncYSZ). In addition, we have also explored the use of optical clearing agents (OCAs) to achieve a local, reversible and temporal reduction of the scalp scattering prior light irradiation. Our results show that the transparent nc-YSZ implants coupled with the OCAs perform well in providing enhanced optical access to the brain tissue, without need for recurrent craniotomies or scalp removal.

Citation Download Citation

Mildred S. Cano-Velázquez, Nami Davoodzadeh, David Halaney, Carrie R. Jonak, Devin K. Binder, Juan Hernández-Cordero, and Guillermo Aguilar "Optical access to the brain through a transparent cranial implant", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341A (21 February 2020); https://doi.org/10.1117/12.2541042

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available