In-vivo and intraoperative SERS in the first and second near infrared windows (Conference Presentation)

Lucas Lane

doi:10.1117/12.2545418

9 March 2020 In-vivo and intraoperative SERS in the first and second near infrared windows (Conference Presentation)

Lucas Lane

Proceedings Volume 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry; 112360B (2020) https://doi.org/10.1117/12.2545418
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Two biologically transparent windows residing within the near-infrared (NIR) spectrum are of substantial interest for in vivo and intraoperative imaging and spectroscopic detection. NIR light penetrates biological tissues more efficiently than visible light because these tissues scatter and absorb less light at longer wavelengths. In particular, my group has developed a class of ‘broad-band’ plasmonic nanostructures that are well suited for strong SERS signals across a broad range of wavelengths allowing a direct comparison of detection sensitivity and tissue penetration between the two NIR windows. Moreover, SERS nanoparticles are generally nontoxic and are much brighter than near-infrared fluorescing probes, raising new possibilities for ultrasensitive detection of microscopic metastases and image-guided tumor resection.

Conference Presentation

Citation Download Citation

Lucas Lane "In-vivo and intraoperative SERS in the first and second near infrared windows (Conference Presentation)", Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 112360B (9 March 2020); https://doi.org/10.1117/12.2545418

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KEYWORDS

Near infrared

In vivo imaging

Surface enhanced Raman spectroscopy

Tissues

Nanoparticles

Plasmonics

Raman scattering

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