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9 March 2020 Free-electron-mediated effects of single femtosecond pulses and pulse series in the (irradiance/fluence) parameter space (Conference Presentation)
Norbert Linz, Xiao-Xuan Liang, Sebastian Freidank, Alfred Vogel
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Proceedings Volume 11238, Optical Interactions with Tissue and Cells XXXI; 1123803 (2020) https://doi.org/10.1117/12.2543680
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Laser-induced plasma generation by single and multiple femtosecond laser pulses is used surgically and constitutes a source of photodamage in nonlinear microscopy. The irradiance threshold at which transient vapor bubbles in water are produced is 20x higher than the irradiance used for nonlinear microscopy. However, photodamage in multiphoton microscopy already starts, when the irradiance is 1.5x above autofluorescence imaging. Thus, there is a huge realm of low-density plasma effects between the multi-pulse damage threshold and the single-pulse surgical regime, and the talk will provide a systematic overview over laser applications and the irradiance and radiant exposure dependence of these effects.
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Norbert Linz, Xiao-Xuan Liang, Sebastian Freidank, and Alfred Vogel "Free-electron-mediated effects of single femtosecond pulses and pulse series in the (irradiance/fluence) parameter space (Conference Presentation)", Proc. SPIE 11238, Optical Interactions with Tissue and Cells XXXI, 1123803 (9 March 2020); https://doi.org/10.1117/12.2543680
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KEYWORDS
Femtosecond phenomena
Multiphoton microscopy
Plasma
Tissues
Laser therapeutics
Microscopy
Surgery
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