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20 February 2020 Visualizing retinal hemorrhage thresholds for Q-switched Nd:YAG lasers in a novel porcine model
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Neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers are among the most commonly used lasers with a wide variety of applications from biomedicine to manufacturing. The ubiquity of these lasers increases the likelihood of accidental ocular injury resulting in permanent visual impairment. We performed dosimetry studies to determine retinal damage thresholds and hemorrhagic lesions in the porcine eye with Qswitched Nd:YAG lasers. The Yucatan miniature pig model exhibited similarities in ocular anatomy to human eyes. The Nd:YAG laser, tuned to 1064 nm with a pulse width of seven nanoseconds, delivered laser energy to the retina. Retinal imaging modalities including fundus photography, real-time video, confocal scanning laser ophthalmoscopy (cSLO), and spectral domain optical coherence tomography (SD-OCT) provided visualization of retinal morphology at multiple time points. Retinal damage thresholds were grouped into three categories: minimum visible lesion (MVL), contained hemorrhagic lesion (CHL), and vitreal hemorrhagic lesion (VHL). Probit analysis determined the effective dose for 50% probability of damage (ED50) for each lesion category. The threshold to produce a MVL was 0.193 mJ based on 24-hour assessments of the retina. The one-hour hemorrhagic lesion thresholds were 0.408 mJ and 1.52 mJ for CHL and VHL, respectively
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Morgan S. Schmidt, Heuy-Ching H. Wang, Gary D. Noojin, William R. Elliot, Peter R. Edsall, Brian Lund, Aurora D. Shingledecker, Amanda Tijerina, Kurt Schuster, and Benjamin A. Rockwell "Visualizing retinal hemorrhage thresholds for Q-switched Nd:YAG lasers in a novel porcine model", Proc. SPIE 11238, Optical Interactions with Tissue and Cells XXXI, 112380U (20 February 2020);

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