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9 March 2020 Genetically-produced and bioinspired magnetic nanoparticles as novel photoacoustic contrast agents (Conference Presentation)
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Abstract
Here, we demonstrated that natural magnetic nanoparticles (nMNP) from magnetotactic bacteria can serve as photoacoustic high-contrast agents for single cell analysis. The main benefits of nMNP include biocompatibility and relatively low laser fluence for photoacoustic detection. These features together with safety of photoacoustics provide potential for clinical translation. Further decoration of nMNP with NIR-absorbing gold nanorods provided hybrid nanoparticles with strong NIR absorption and plasmonic effects for cancer cell theranostics. In studies in vivo, we showed that circulating tumor cells labeled with bioinspired hybrids generated transient ultrasharp photoacoustic resonances as the basis for new super-resolution photoacoustic flow cytometry in vivo.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Julia Watts, Mikyung Han, Mustafa Sarimollaoglu, Zeid A. Nima, Fumiya Watanabe, Azemat Jamshidi-Parsian, Alexandru Biris, Vladimir Zharov, and Ekaterina Galanzha "Genetically-produced and bioinspired magnetic nanoparticles as novel photoacoustic contrast agents (Conference Presentation)", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 1123904 (9 March 2020); https://doi.org/10.1117/12.2550396
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