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We apply time-domain diffuse correlation spectroscopy (TD DCS) to quantify dynamics in samples with mixed dynamics, containing both static and dynamic scatterers. We demonstrate that standard TD DCS processing is incapable to properly quantify dynamics at short source-detector distances due to the strong influence of the static component. To solve this problem, we introduce a novel model, which allows recovering the autocorrelation decay of the dynamic part properly. We then apply this novel approach in humans in vivo. We recovered the blood flow index of the leg muscle covered by the thin static turbid layer during the cuff occlusion challenge.
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Dawid Borycki, Saeed Samaei, Michal Kacprzak, Piotr Sawosz, Adam Liebert, "Time-domain diffuse correlation spectroscopy of turbid media with mixed dynamics (Conference Presentation)," Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 1123906 (9 March 2020); https://doi.org/10.1117/12.2545598