Identification of intestinal fibrosis using spectroscopic photoacoustic imaging: feasibility study in human subjects (Conference Presentation)

Yunhao Zhu; Laura Johnson; Jonathan Rubin; Jie Yuan; Xueding Wang; Peter Higgins; Guan Xu

doi:10.1117/12.2544299

6 March 2020 Identification of intestinal fibrosis using spectroscopic photoacoustic imaging: feasibility study in human subjects (Conference Presentation)

Yunhao Zhu, Laura Johnson, Jonathan Rubin, Jie Yuan, Xueding Wang, Peter Higgins, Guan Xu

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124007 (2020) https://doi.org/10.1117/12.2544299
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Identifying fibrosis against inflammation in the intestinal strictures is critical to the management of CD. Our pioneering study has shown that spectroscopic photoacoustic (PA) imaging is capable of differentiating inflammatory and fibrotic intestinal strictures in animals in vivo. We also validated the feasibility of acquiring PA signals from intestinal strictures transcutaneously. In this study, we further investigated the capability of transcutaneous PA imaging in characterizing intestinal inflammation and fibrosis in human subjects. The findings in PA imaging were validated by US Doppler images and histopathology.

Conference Presentation

Citation Download Citation

Yunhao Zhu, Laura Johnson, Jonathan Rubin, Jie Yuan, Xueding Wang, Peter Higgins, and Guan Xu "Identification of intestinal fibrosis using spectroscopic photoacoustic imaging: feasibility study in human subjects (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124007 (6 March 2020); https://doi.org/10.1117/12.2544299

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