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20 April 2020 Chromophore selective multi-wavelength photoacoustic remote sensing (Conference Presentation)
Nicholas Pellegrino, Saad R. Abbasi, Kevan Bell, Deepak Dinakaran, Gilbert Bigras, John R. Mackey, Paul Fieguth, Parsin Haji Reza
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Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112400H (2020) https://doi.org/10.1117/12.2546721
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
To assess cancer resection margins, post-operative histological diagnosis using hematoxylin and eosin (H&E) stained slides remains the gold standard due to the lack of effective intra-operative approaches. Wait times may be up to two weeks and subsequent treatments may be necessary. Therefore, we are motivated to introduce Chromophore Selective Multi-Wavelength Photoacoustic Remote Sensing, an all-optical, non-contact, reflection-mode, label-free approach to produce H&E-like images of human tissue. This work is a step towards in-situ imaging, rapid clinical assessment of tissue, and may permit future developments as a live intraoperative surgical microscope.
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Nicholas Pellegrino, Saad R. Abbasi, Kevan Bell, Deepak Dinakaran, Gilbert Bigras, John R. Mackey, Paul Fieguth, and Parsin Haji Reza "Chromophore selective multi-wavelength photoacoustic remote sensing (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400H (20 April 2020); https://doi.org/10.1117/12.2546721
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KEYWORDS
Chromophores
Photoacoustic spectroscopy
Remote sensing
Tissues
Cancer
Surgery
Gold
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