Heartbeat OCE: Corneal biomechanical response to simulated heartbeat pulsation

Achuth Nair; Manmohan Singh; Salavat R. Aglyamov; Kirill V. Larin

doi:10.1117/12.2546196

13 February 2020 Heartbeat OCE: Corneal biomechanical response to simulated heartbeat pulsation

Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin

Proceedings Volume 11242, Optical Elastography and Tissue Biomechanics VII; 1124205 (2020) https://doi.org/10.1117/12.2546196
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The biomechanical properties of the cornea can be an important biomarker for assessing tissue health. In this work, we evaluated cornea biomechanical properties during intraocular pressure fluctuation simulating heartbeat induced corneal pulse. This method results in a more physiologically relevant assessment of tissue mechanics, and thus diverges from typical elastography techniques that rely on externally induced deformation. Optical coherence tomography is used to detect displacements in the cornea as IOP is cycled. The axial strains within the cornea are calculated from these displacements, so that dynamic changes in stiffness can be determined. The results indicate a gradient in axial displacement within the cornea and illustrate a distinct difference in strain between the untreated and crosslinked tissues. This suggests that heartbeat OCE may be a useful technique in assessing stiffness of the cornea.

Citation Download Citation

Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, and Kirill V. Larin "Heartbeat OCE: Corneal biomechanical response to simulated heartbeat pulsation", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 1124205 (13 February 2020); https://doi.org/10.1117/12.2546196

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