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9 March 2020 Optical coherence tomography based Vibrometry as a probe of cochlear mechanics (Conference Presentation)
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Abstract
The exquisite phase sensitivity of Optical Coherence Tomography (OCT) has enabled the development of sensitive spatially resolved vibrometers. Using this technology, it is possible to measure vibratory response in live animals and humans down to a few picometers in amplitude. We are employing this technology in animal models to probe the mechanics of the cochlea, the part of the inner ear responsible for hearing. OCT based Vibrometry (OCTV) can image through the bone to capture morphological and functional images of the soft tissues within the cochlea. These measurements have led to new understandings of the mechanical processing of sound. Through recent advances it is now possible to make completely noninvasive OCTV measurements in awake mice. This has enabled studies including feedback from the efferent nerves that are shutdown in an anesthetized animal. These and related optical technologies are making a significant impact on our understanding of the mechanics of hearing.
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Brian E. Applegate "Optical coherence tomography based Vibrometry as a probe of cochlear mechanics (Conference Presentation)", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 112420V (9 March 2020); https://doi.org/10.1117/12.2552939
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