CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11244 > Article
Presentation
9 March 2020 Quantification of blood-brain barrier permeability with multiphoton fluorescence imaging (Conference Presentation)
Lingyan Shi
Author Affiliations +
Proceedings Volume 11244, Multiphoton Microscopy in the Biomedical Sciences XX; 112440T (2020) https://doi.org/10.1117/12.2544525
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Development of an optimal systemic drug delivery strategy to the brain will require non- invasive or minimally invasive methods to quantify the permeability of the cerebral microvessel wall or blood-brain barrier (BBB) to various therapeutic agents and to mea- sure their transport in the brain tissue.We developed a new drug delivery technique combine with multiphoton fluorescence imaging to quantify the BBB permeability. We then further applied ultrasound sonication combined with microbubble injection to open the BBB for drug delivery. The transient increase of BBB permeability was imaged and quantified by using multiphoton fluorescence microscopy.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Lingyan Shi "Quantification of blood-brain barrier permeability with multiphoton fluorescence imaging (Conference Presentation)", Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112440T (9 March 2020); https://doi.org/10.1117/12.2544525
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Multiphoton fluorescence microscopy
Blood brain barrier
Brain
Tissues
Bone
Diffusion
Laser tissue interaction
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top