Hybrid photoacoustic and fluorescence endomicroscopy through a multimode fiber via transmission-matrix-based optical wavefront shaping (Conference Presentation)

Sylvain Mezil; Irène Wang; Philippe Moreau; Théodore Remark; Antonio M. Caravaca-Aguirre; Emmanuel Bossy

doi:10.1117/12.2546165

11 March 2020 Hybrid photoacoustic and fluorescence endomicroscopy through a multimode fiber via transmission-matrix-based optical wavefront shaping (Conference Presentation)

Sylvain Mezil, Irène Wang, Philippe Moreau, Théodore Remark, Antonio M. Caravaca-Aguirre, Emmanuel Bossy

Author Affiliations +

Proceedings Volume 11248, Adaptive Optics and Wavefront Control for Biological Systems VI; 112480V (2020) https://doi.org/10.1117/12.2546165
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

One limitation of microendoscopy is the device footprint that should be minimal for many applications. Here we present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. With the use of a fast spatial-light modulator, it is possible to rapidly learn the transmission matrix during a prior calibration step. A focused spot can then be produced to raster-scan a sample at the distal tip of the fiber. Our setup provides both photoacoustic and fluorescence microscopic images of test samples in vitro (fluorescent beads and red blood cells) through a single multimode fiber.

Conference Presentation

Citation Download Citation

Sylvain Mezil, Irène Wang, Philippe Moreau, Théodore Remark, Antonio M. Caravaca-Aguirre, and Emmanuel Bossy "Hybrid photoacoustic and fluorescence endomicroscopy through a multimode fiber via transmission-matrix-based optical wavefront shaping (Conference Presentation)", Proc. SPIE 11248, Adaptive Optics and Wavefront Control for Biological Systems VI, 112480V (11 March 2020); https://doi.org/10.1117/12.2546165

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