Optical coherence tomography (OCT) suffers from speckle noise due to use of spatially coherent light, leading to significant reductions in image quality. Angular compounding techniques have been applied to remove speckle noise, but, existing image registration methods only guarantee pure angular compounding in the focal plane and produce spatial averaging in the defocused regions. This work develops an image registration model to correctly localize the real-space location of every pixel in OCT images captured at multiple incident angles, with digital focusing to further increase the lateral resolution and contrast. In the composite image, speckle suppression and resolution enhancement are realized.
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