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21 February 2020 Fast, compact measurement of deep tissue blood flow with integrated diffuse correlation spectroscopy
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Diffuse Correlation Spectroscopy (DCS) is a widely used non-invasive measurement technique to quantitatively estimate deep tissue blood flow. In recent years, newer approaches to blood flow measurement with DCS, Diffuse Speckle Contrast Analysis (DSCA) and Speckle Contrast Optical Spectroscopy (SCOS), have adapted speckle contrast analysis methods to simplify deep tissue blood flow measurements using cameras and SPAD arrays as detectors. In this paper, we introduce and demonstrate a new integrated DCS (iDCS) detector, a novel optical sensor setup which leverages diffuse speckle contrast analysis for probe-level quantitative measurement tissue blood flow. In iDCS, a normal photodiode is used in photovoltaic mode to integrate photon intensity fluctuations over multiple integration times as opposed to the high frequency sampling of photon counts with DCS. The iDCS detector scheme features small form factor, low cost, simple instrument design. Preliminary in-vivo experiments on the forearm of a subject, during arm-cuff occlusion, showed ~100% relative change in blood flow which is comparable to blood flow changes measured using traditional DCS.
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Arindam Biswas and Ashwin B. Parthasarathy "Fast, compact measurement of deep tissue blood flow with integrated diffuse correlation spectroscopy", Proc. SPIE 11253, Biomedical Applications of Light Scattering X, 112530W (21 February 2020);

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