Nanoplasmonic imaging biosensor for digital detection of disease biomarkers (Conference Presentation)

Alexander Belushkin; Filiz Yesilkoy; Hatice Altug

doi:10.1117/12.2545619

10 March 2020 Nanoplasmonic imaging biosensor for digital detection of disease biomarkers (Conference Presentation)

Alexander Belushkin, Filiz Yesilkoy, Hatice Altug

Proceedings Volume 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII; 1125406 (2020) https://doi.org/10.1117/12.2545619
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We present a nanoparticle (NP) enhanced imaging-based plasmonic biosensing technique using gold nanohole arrays (Au-NHAs) that enables highly sensitive protein detection with single analyte resolution in a one-step sandwich immunoassay. By digital quantification of individual Au-NP bound molecules on large area plasmonic surface, the portable biosensor enables rapid and robust detection of disease biomarkers from patient serum in hospital settings. Using mass-scalable deep-UV lithography (DUVL) sensor fabrication and simple LED based imaging set-up in a microarray format, our novel technology provides a powerful tool for clinical biomarker detection in a highly multiplexed manner.

Conference Presentation

Citation Download Citation

Alexander Belushkin, Filiz Yesilkoy, and Hatice Altug "Nanoplasmonic imaging biosensor for digital detection of disease biomarkers (Conference Presentation)", Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 1125406 (10 March 2020); https://doi.org/10.1117/12.2545619

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