Patterns of interaction of the cell membrane with a matrix of natural polymers and carbon nanotubes

Olga E. Glukhova; Michael M. Slepchenkov

doi:10.1117/12.2546746

21 February 2020 Patterns of interaction of the cell membrane with a matrix of natural polymers and carbon nanotubes

Olga E. Glukhova, Michael M. Slepchenkov

Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 112560Q (2020) https://doi.org/10.1117/12.2546746
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this work, we investigate in silico the patterns of the interaction of natural polymer matrices based on a network of single-walled carbon nanotubes (SWCNTs), albumin and collagen with the cell membrane. A layer of phospholipid molecules is considered as a cell membrane. The simulation is carried by means of the coarse-grained approach using the MARTINI force field. During the simulation of contact of the membrane with the matrix, the membrane moved to the matrix with an average blood flow velocity of 0.5 m/s, which simulates the collision of blood elements with the surface of the SWCNT-natural polymer matrix. It is established that during the interaction of natural polymer matrices with cell membranes, the matrices do no harm to the cell membrane.

Citation Download Citation

Olga E. Glukhova and Michael M. Slepchenkov "Patterns of interaction of the cell membrane with a matrix of natural polymers and carbon nanotubes", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560Q (21 February 2020); https://doi.org/10.1117/12.2546746

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