Plasmonic nanoparticles in agarose gel and filter paper-integrated microfluidic devices for SERS detection of molecules

Li-An Wu; Yun-Chu Chen; Wen-Chi Pai; Yun-Hsian Hsu; Yih-Fan Chen

doi:10.1117/12.2544360

21 February 2020 Plasmonic nanoparticles in agarose gel and filter paper-integrated microfluidic devices for SERS detection of molecules

Li-An Wu, Yun-Chu Chen, Wen-Chi Pai, Yun-Hsian Hsu, Yih-Fan Chen

Author Affiliations +

Proceedings Volume 11257, Plasmonics in Biology and Medicine XVII; 1125702 (2020) https://doi.org/10.1117/12.2544360
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We will present surface enhanced Raman spectroscopy (SERS) detection of molecules using plasmonic nanoparticles that are embedded in agarose gel and in filter paper-integrated microfluidic channels, respectively. It has been known that, when SERS detection is performed in complex fluids such as cell culture media, a method to reduce interferences from a variety of molecules in the fluids on the detection results is very important. If continuous monitoring of molecules in cell culture media is needed, there should be a method to prevent large molecules such as proteins from reaching SERS substrates when sample solutions flow over the substrates. Since both agarose gel and filter paper can be used to separate molecules by size, in this study we have integrated them with plasmonic nanoparticles for SERS detection in complex fluids. We will report how to use filter paper-integrated microfluidic channels to detect melamine and sodium thiocyanate (NaSCN) in milk using SERS. In addition, we will demonstrate how to use plasmonic agarose gels to detect illegal drug in urine.

Citation Download Citation

Li-An Wu, Yun-Chu Chen, Wen-Chi Pai, Yun-Hsian Hsu, and Yih-Fan Chen "Plasmonic nanoparticles in agarose gel and filter paper-integrated microfluidic devices for SERS detection of molecules", Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 1125702 (21 February 2020); https://doi.org/10.1117/12.2544360

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