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10 March 2020 Magnetically aggregated biosensors for sensitive detection of biomarkers at low concentrations (Conference Presentation)
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Abstract
Detection of biomarkers at low concentrations is essential for early diagnosis of numerous diseases. In many sensitive assays, the target molecules are tagged using fluorescently labeled probes and captured using magnetic beads. Current devices rely on quantifying the target molecules by detecting the fluorescent signal from individual beads. Here, we propose a compact fluorescence-based magnetically aggregated biosensors (MAB) system. Using the device to detect human Interleukin-8, we demonstrated a 0.1 ng/L limit of detection and a 4-log dynamic range, performance which is on par with the most sensitive devices, but is achieved without their bulk and cost.
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© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Shmuel Burg, Meir Cohen, Michael Margulis, Shira Roth, and Amos Danielli "Magnetically aggregated biosensors for sensitive detection of biomarkers at low concentrations (Conference Presentation)", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125803 (10 March 2020); https://doi.org/10.1117/12.2543206
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