Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

E. Popova-Kuznetsova; G. Tikhonowski; A. A. Popov; V. R. Duflot; S. M. Deyev; S. M. Klimentov; I. N. Zavestovskaya; P. N. Prasad; A. V. Kabashin

doi:10.1117/12.2551432

2 March 2020 Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

E. Popova-Kuznetsova, G. Tikhonowski, A. A. Popov, V. R. Duflot, S. M. Deyev, S. M. Klimentov, I. N. Zavestovskaya, P. N. Prasad, A. V. Kabashin

Author Affiliations +

Proceedings Volume 11269, Synthesis and Photonics of Nanoscale Materials XVII; 1126904 (2020) https://doi.org/10.1117/12.2551432
Event: SPIE LASE, 2020, San Francisco, California, United States

Abstract

Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of ¹⁵³Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.

Conference Presentation

Citation Download Citation

E. Popova-Kuznetsova, G. Tikhonowski, A. A. Popov, V. R. Duflot, S. M. Deyev, S. M. Klimentov, I. N. Zavestovskaya, P. N. Prasad, and A. V. Kabashin "Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine", Proc. SPIE 11269, Synthesis and Photonics of Nanoscale Materials XVII, 1126904 (2 March 2020); https://doi.org/10.1117/12.2551432

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available