A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype

Xinbin Li; Zhiqiang Chen; Li Zhang; Hewei Gao; Chengpeng Wu; Xiaohua Zhu

doi:10.1117/12.2549560

16 March 2020 A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype

Xinbin Li, Zhiqiang Chen, Li Zhang, Hewei Gao, Chengpeng Wu, Xiaohua Zhu

Proceedings Volume 11312, Medical Imaging 2020: Physics of Medical Imaging; 113121A (2020) https://doi.org/10.1117/12.2549560
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

By integrating three absorption gratings with a medical X-ray tube and a medical flat panel detector, a preclinical X-ray multi-contrast lung imaging prototype with a large field-of-view up to 40 × 50 cm² was developed in this work. The prototype system provides phase-contrast and dark-field images simultaneously in addition to the conventional X-ray absorption imaging. Unlike the traditional grating-based phase-contrast imaging (GPCI) system, the scanning object is placed behind the pattern-generating grating G1, reducing the radiation dose to probably half of the original system design. For a fast scan process, three absorption gratings inducing a large field-of-view were utilized. Besides, the X-ray tube, the three gratings and the detector are all fixed on the same mechanical arm, scanning the object along the vertical direction. A numerical simulation platform was developed to help optimize the imaging parameters. Finally, the preliminary experimental results of a full-body enthanized rabbit demonstrate the capability of the multi-contrast prototype system, and its dark-field images are capable of providing additional diagnostic value for the diagnosis of lung diseases. Direct evaluation of the potential clinical unity of the multi-contrast lung imaging can be further performed on this prototype system.

Conference Presentation

Citation Download Citation

Xinbin Li, Zhiqiang Chen, Li Zhang, Hewei Gao, Chengpeng Wu, and Xiaohua Zhu "A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype", Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113121A (16 March 2020); https://doi.org/10.1117/12.2549560

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