Computer Vision Syndrome (CVS) is an umbrella term for a pattern of symptoms associated with prolonged digital screen exposure such as eyestrain, headaches, blurred vision, dry eyes, and neck/shoulder pain. Commercially available blue light filtering lenses (BLFL) are advertised as improving CVS. This pilot study evaluated the effectiveness of BLFL on reducing CVS symptoms and fatigue in a cohort of radiology trainees. In this Institutional Review Board approved prospective crossover study, 10 radiology residents were randomized into two cohorts: one wearing BLFL first then a sham pair (non-BLFL), and the other wearing a sham pair first then the BLFL over the course of a typical clinical work day for 5 days. Every evening, participants filled out a questionnaire based on a previously validated CVS questionnaire (CVS-Q:16 questions, Likert scale 1-5) and the Swedish Occupational Fatigue Index (SOFI: 16 questions, Likert scale 0- 10). 10 radiology residents (8 PGY-2, 1 PGY-3, and 1 PGY-4): 4 males, 6 females, participated. Although none of the 32 symptoms demonstrated statistically significant differences, 11/16 (68.8%) symptoms measured on the CVS-Q and 13/16 (81.3%) symptoms measured on the SOFI were reduced with the BLFL compared to the sham glasses. Two symptoms, “drowsy” and “lack of concern,” decreased in the BLFL cohort nearing statistical significance, p = 0.057 and p = 0.075, respectively. Use of BLFL may ameliorate CVS symptoms. Future studies with larger sample sizes and participants of different ages are required to verify the potential of BLFL.