Translator Disclaimer
16 March 2020 Computer extracted features related to the spatial arrangement of tumor-infiltrating lymphocytes predict overall survival in epithelial ovarian cancer receiving adjuvant chemotherapy
Author Affiliations +
Abstract
The presence of tumor-infiltrating lymphocytes (TILs) is correlated with outcome and prognosis in epithelial ovarian cancer (EOC). In this study, automated image analysis was used to analyze the association between overall survival (OS) and TIL spatial arrangement and density in a multi-site cohort of 102 EOC patients who received adjuvant chemotherapy following debulking surgery. Features of the spatial arrangement of TILs (SpaTIL) were used to quantify the spatial co-localization of TILs and tumor cells on digitized pathology slides of the malignant neoplasm of excised specimens. A multivariable Cox regression model of SpaTIL features was fit on the n1 = 51 patient training set and was evaluated in the n2 = 51 patient validation set. The SpaTIL signature was significantly associated with OS, both in the training set (hazard ratio (HR) = 2.81, 95% confidence interval (CI) = 1.33 − 5.92, and p = 0.003) and the validation set (HR = 2.06, 95% CI = 1.04 − 4.07, and p = 0.008). In addition, fusing our spaTIL risk score and the clinical staging further improved the results of the predictive model (HR = 4.045, 95% CI = 4.11−5.41, and p = 0.0002 in the validation set) and outperformed clinical staging alone. This finding illustrates that a spaTIL risk score is not only able to predict OS independent of clinical data, but also offers prognostic value complementary to current clinical standard-of-care. Patients with longer survival times had significantly higher heterogeneity of non-TIL cluster area, while shorter time survivors had mostly same-sized, evenly-distributed non-TIL clusters and smaller average TIL cluster area. These findings suggest that dispersion of TILs throughout the tumor is associated with better treatment response to post-treatment adjuvant chemotherapy, and therefore longer survival time.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sepideh Azarianpour, Germán Corredor, Kaustav Bera, Patrick Leo, Nathaniel Braman, Pingfu Fu, Haider Mahdi, and Anant Madabhushi "Computer extracted features related to the spatial arrangement of tumor-infiltrating lymphocytes predict overall survival in epithelial ovarian cancer receiving adjuvant chemotherapy", Proc. SPIE 11320, Medical Imaging 2020: Digital Pathology, 113200Q (16 March 2020); https://doi.org/10.1117/12.2550188
PROCEEDINGS
10 PAGES + PRESENTATION

SHARE
Advertisement
Advertisement
Back to Top