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2 April 2020 Optical fine needle biopsy in hepatocellular carcinoma mouse model
Elena Potapova, Ksenia Kandurova, Valery Shupletsov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Yuri Ivanov, Dmitry Panchenkov, Andrey Dunaev
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Proceedings Volume 11363, Tissue Optics and Photonics; 113630V (2020) https://doi.org/10.1117/12.2555154
Event: SPIE Photonics Europe, 2020, Online Only
Abstract
The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis.
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Elena Potapova, Ksenia Kandurova, Valery Shupletsov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Yuri Ivanov, Dmitry Panchenkov, and Andrey Dunaev "Optical fine needle biopsy in hepatocellular carcinoma mouse model", Proc. SPIE 11363, Tissue Optics and Photonics, 113630V (2 April 2020); https://doi.org/10.1117/12.2555154
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KEYWORDS
Tumors
Liver
Biopsy
Luminescence
Diffuse reflectance spectroscopy
Cancer
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