27 November 1989 Application Of Synchrotron Radiation To The Imaging Of Coronary Arteries
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The tunable energy, high intensity and high collimation of X-ray beams from synchrotron radiation sources may provide a less invasive method to acquire images of human coronary arteries. Currently the standard imaging procedure is dangerous since it requires that a catheter be inserted into a peripheral artery and threaded up to the heart so that a contrast agent can be injected directly into the artery being imaged. Using a pair of X-ray images taken with monochromatized X-ray beams from a synchrotron, it may be possible to use a much safer venous injection of a contrast agent and still have sufficient image contrast to visualize the coronary arteries. The energies of the beams are arranged to bracket the iodine K absorption edge where the iodine absorption cross section jumps by a factor of six. The logarithmic difference image has excellent sensitivity to contrast agent and minimal sensitivity to tissue and bone. A new imaging system has been built that uses a dual beam monochromator and dual array detector. Two sets of transvenous arterial images have been acquired with it of a patient with severe coronary artery disease.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
A. C. Thompson, E. Rubenstein, R. S. Kernoff, H. Zeman, N. Gmur, W. Thomlinson, R. Hofstadter, J. C. Giacomini, H. J. Gordon, and G. S. Brown "Application Of Synchrotron Radiation To The Imaging Of Coronary Arteries", Proc. SPIE 1140, X-Ray Instrumentation in Medicine and Biology, Plasma Physics, Astrophysics, and Synchrotron Radiation, (27 November 1989); doi: 10.1117/12.961824; https://doi.org/10.1117/12.961824

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