Fourier Transform Infrared Spectroscopy Demonstrates The Reactivity Of The Protonated Carboxyl Group Of The Acid Salt Of Calcium Bilirubinate.

R. D. Soloway; J-G Wu; D-F Xu; Y-F Zhang; D. K. Martini; N-K Hong; R. S. Crowther

doi:10.1117/12.969451

1 December 1989 Fourier Transform Infrared Spectroscopy Demonstrates The Reactivity Of The Protonated Carboxyl Group Of The Acid Salt Of Calcium Bilirubinate.

R. D. Soloway, J-G Wu, D-F Xu, Y-F Zhang, D. K. Martini, N-K Hong, R. S. Crowther

Author Affiliations +

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969451
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

Calcium bilirubinate is a major salt in pigment gallstones. Bilirubin IX (H2BR) is a tetrapyrrole with 1 propionic acid side chain on both the B and C rings. A striking feature is the strong intramolecular hydrogen bonding of both carboxyl groups as determined by x-ray diffraction. This greatly reduces aqueous solubility. Much less is known about the structure of the salts of calcium bilirubinate since single crystals have not been formed. One or both carboxyl groups of bilirubin may coordinate with calcium in stone, forming the acid or neutral salt.

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R. D. Soloway, J-G Wu, D-F Xu, Y-F Zhang, D. K. Martini, N-K Hong, and R. S. Crowther "Fourier Transform Infrared Spectroscopy Demonstrates The Reactivity Of The Protonated Carboxyl Group Of The Acid Salt Of Calcium Bilirubinate.", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969451

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