Vibrational Circular Dichroism Studies Of Interchain Hydrogen Bonding In Tripodal Peptide Molecules

M. G. Paterlini; T. B. Freedman; L. A. Nafie; Y. Tor; A. Shanzer

doi:10.1117/12.969400

1 December 1989 Vibrational Circular Dichroism Studies Of Interchain Hydrogen Bonding In Tripodal Peptide Molecules

M. G. Paterlini, T. B. Freedman, L. A. Nafie, Y. Tor, A. Shanzer

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969400
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

Vibrational circular dichroism (VCD) has been used to determine the solution structures of three tripodal peptide molecules. The interchain hydrogen bonding is shown to be oriented in a clockwise direction (from C=0 to NH) by application of the coupled oscillator mechanism in the carbonyl stretching region. The carbonyls of the terminal Boc groups are found to be oriented in a counterclockwise direction. Open chain conformations and dimers are also present in solution and contribute to the VCD spectra with monosignate intensity that is interpreted using the ring current mechanism.

Citation Download Citation

M. G. Paterlini, T. B. Freedman, L. A. Nafie, Y. Tor, and A. Shanzer "Vibrational Circular Dichroism Studies Of Interchain Hydrogen Bonding In Tripodal Peptide Molecules", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969400

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