Optics based in vivo assessment of brain stiffness

H. Ferdinando; T. Myllylä

doi:10.1117/12.2565621

9 April 2020 Optics based in vivo assessment of brain stiffness

H. Ferdinando, T. Myllylä

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 1145705 (2020) https://doi.org/10.1117/12.2565621
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

Light-tissue interactions caused by cardiac pulses in blood vessels and tissue boundaries give rise to several pulse components in the measurement volume of a diffused optical signal. These pulses can be used to reconstruct the optical waveform and to estimate such phenomenon as arterial stiffness. Commonly, this is done by using so called pulse decomposition analysis. In functional near-infrared spectroscopy (fNIRS) based brain studies cardiac pulses are typically low pass filtered as an artefact, because normally of interest are low frequency fluctuations in fNIRS signal that reflect neural activations. Here we focus on analysis on the cardiac pulse that is usually visible in unfiltered fNIRS signals measured from the brain and propose the use of fNIRS and pulse decomposition analysis for in vivo assessment of brain tissue stiffness. We study possibilities to distinguish different wave components from the cardiac pulse in fNIRS signal when measuring the brain cortex using source-detector separation distance of 3 cm. Since cardiac pulses, particularly central artery pulse, and blood pressure changes cause pulsatile motion in the brain tissue we hypothesize that this pulsation can reflect brain tissue stiffness and/or changes in intracranial pressure (ICP), which are important parameters for brain health. Further, this analysis technique could be eventually utilized in diagnostics of brain disorders, for instance, brain edema and neurodegeneration related disorders such as dementia.

Citation Download Citation

H. Ferdinando and T. Myllylä "Optics based in vivo assessment of brain stiffness", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 1145705 (9 April 2020); https://doi.org/10.1117/12.2565621

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Arteries

Tissues

In vivo imaging

Tissue optics

Blood

Near infrared spectroscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years