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9 April 2020 Erythrocyte aggregation stimulated by NaYF4:Er3+,Yb3+ upconversion nanoparticles
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Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570D (2020) https://doi.org/10.1117/12.2559853
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation
Abstract
When administered into the bloodstream, upconversion nanoparticles used in therapeutic / diagnostic purposes can affect red blood cells. In this work, using light optical microscopy, we show that the removal of citrate groups from the surface of NaYF4: Er3+ , Yb3+ nanoparticles synthesized by the hydrothermal method prevents the formation of large clod-like aggregates from a suspension of washed rat erythrocytes incubated with the nanoparticles. However, the tendency toward a change in cell shape with an increase in nanoparticles concentration is still manifested.
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Anna Doronkina, Natalia Kazadaeva, Elena Sagaidachnaya, Irina Yanina, Alexander Skaptsov, Yulia Konyukhova, Alexander Pravdin, Vyacheslav Kochubey, and Nikita Navolokin "Erythrocyte aggregation stimulated by NaYF4:Er3+,Yb3+ upconversion nanoparticles", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570D (9 April 2020); https://doi.org/10.1117/12.2559853
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