Biophotonics approach for the study of leukocyte activation

Daria N. Chernova; Sergei G. Sokolovski; Alexey Yu. Vorobev; Alexander E. Moskalensky

doi:10.1117/12.2560325

9 April 2020 Biophotonics approach for the study of leukocyte activation

Daria N. Chernova, Sergei G. Sokolovski, Alexey Yu. Vorobev, Alexander E. Moskalensky

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570G (2020) https://doi.org/10.1117/12.2560325
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

Leukocytes are the main cells of immune system, but also contribute to other systems and participate in pathogenesis of different diseases. In particular, leukocytes are involved in the progression of diabetic retinopathy due to their hyperactivation in diabetes. However, a connection between diabetes and the dysfunction of leukocytes is poorly understood. For a more complete picture, studies of the leukocytes activation under the influence of various substances are necessary. Arachidonic acid (AA) and its metabolites are the strongest activating factors of leukocytes. However, the studies involving AA are complicated because it is water-insoluble. Here we describe the method to study activation using photolabile analogs of AA.

Citation Download Citation

Daria N. Chernova, Sergei G. Sokolovski, Alexey Yu. Vorobev, and Alexander E. Moskalensky "Biophotonics approach for the study of leukocyte activation", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570G (9 April 2020); https://doi.org/10.1117/12.2560325

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KEYWORDS

Calcium

Biomedical optics

Luminescence

Ultraviolet radiation

Microscopes

Absorption

Microscopy

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