Pilot study of glycerol diffusion in ex vivo skin: a comparison of alloxan and streptozotocin diabetes models

Daria K. Tuchina; Alla B. Bucharskaya; Valery V. Tuchin

doi:10.1117/12.2563794

9 April 2020 Pilot study of glycerol diffusion in ex vivo skin: a comparison of alloxan and streptozotocin diabetes models

Daria K. Tuchina, Alla B. Bucharskaya, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570J (2020) https://doi.org/10.1117/12.2563794
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

Two models of diabetes, such as alloxan and streptozotocin, were used in the study to verify the influence of both on the optical properties and molecular permeability of skin ex vivo. Kinetics of collimated transmittance of control and diabetic skin samples immersed in aqueous 70%-glycerol solution was measured and then processed for estimation of diffusion coefficient of glycerol in skin. As a result, the slower glycerol diffusion rate was observed for both models of diabetes.

Citation Download Citation

Daria K. Tuchina, Alla B. Bucharskaya, and Valery V. Tuchin "Pilot study of glycerol diffusion in ex vivo skin: a comparison of alloxan and streptozotocin diabetes models", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570J (9 April 2020); https://doi.org/10.1117/12.2563794

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available