Compacted optical endoscopic probe for in vivo fluorescence optical imaging device

Hyeonjin Bang; Byungjun Park; Kiri Lee; Byungyeon Kim; Minsuk Lee; Sungjun Hong; Seungrag Lee

doi:10.1117/12.2566090

20 August 2020 Compacted optical endoscopic probe for in vivo fluorescence optical imaging device

Hyeonjin Bang, Byungjun Park, Kiri Lee, Byungyeon Kim, Minsuk Lee, Sungjun Hong, Seungrag Lee

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Proceedings Volume 11484, Optical Modeling and Performance Predictions XI; 114840L (2020) https://doi.org/10.1117/12.2566090
Event: SPIE Optical Engineering + Applications, 2020, Online Only

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Abstract

We have developed a compact optical endoscopic probe for in vivo fluorescence optical imaging device. We obtained fluorescence image for the colon tissue of a mouse using a compacted optical endoscopic probe with a designed endoscopic optical lens. In order to demonstrate endoscopic fluorescence imaging for the colon cancer, we have manufactured a compacted optical endoscopic probe to pass through the biopsy channel of electric flexible endoscope. The compacted optical endoscopic probe with maximum outside diameter of 2.8mm consists of fiber-optic illumination part and imaging part. The imaging part consists of a fiber-optic imaging bundle linked to an endoscopic optical lens and focus assembly. We considered a compact structure, sensitivity, and FOV for the design of the endoscopic optical lens. We have suggested an endoscopic optical lens with an FOV of 90 ° and DOF of 3 – 80mm. The optical system consists of glass-based aspheric lenses. The total track is less than 2.5 mm, and the diameter is limited to less than 1.5 mm to obtain a compact system. We have presented the compacted optical endoscopic probe for cancer imaging of a mouse. The proposed endoscopic optical lens showed sufficient sensitivity and a wide field of view for obtaining fluorescence imaging. We demonstrated endoscopic ex vivo fluorescence imaging for the colon cancer of a mouse using the compacted optical endoscopic probe.

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Hyeonjin Bang, Byungjun Park, Kiri Lee, Byungyeon Kim, Minsuk Lee, Sungjun Hong, and Seungrag Lee "Compacted optical endoscopic probe for in vivo fluorescence optical imaging device", Proc. SPIE 11484, Optical Modeling and Performance Predictions XI, 114840L (20 August 2020); https://doi.org/10.1117/12.2566090

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