Translator Disclaimer
Paper
22 May 2020 Three-dimensional visualization of cribriform pattern in ductal carcinoma in situ with x-ray dark field computed tomography
Author Affiliations +
Proceedings Volume 11513, 15th International Workshop on Breast Imaging (IWBI2020); 115131X (2020) https://doi.org/10.1117/12.2563940
Event: Fifteenth International Workshop on Breast Imaging, 2020, Leuven, Belgium
Abstract
Cribriform architecture is a histological pattern reminiscent of Swiss cheese that is commonly recognized in ductal carcinoma in situ (DCIS) of the breast observed by microscope. However, there are only a few three-dimensional studies to elucidate whether each glandular cavities of cribriform pattern are connected or not. The main reason for paucity of three-dimensional studies is that the conventional reconstruction based on histological sections requires laborious and time-consuming works. In this research, we first performed three-dimensional reconstruction of the cribriform pattern using crystal analyzer-based phase contrast technique, X-ray dark field computed tomography (XDFI-CT), which provides high contrast image of biological soft tissue with non-destructive and non-staining approach. Then, we propose a machine-learning-based method to extract the cavity from XDFI-CT images. Finally, we show that the useful information to analyze the cribriform patterns in DCIS such as the density and volume of the cavity can be obtained from the XDFI-CT images.
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
N. Sunaguchi, Z. Huang, D. Shimao, T. Yuasa, S. Ichihara, R. Nishimura, A. Iwakoshi, and M. Ando "Three-dimensional visualization of cribriform pattern in ductal carcinoma in situ with x-ray dark field computed tomography", Proc. SPIE 11513, 15th International Workshop on Breast Imaging (IWBI2020), 115131X (22 May 2020); https://doi.org/10.1117/12.2563940
PROCEEDINGS
6 PAGES


SHARE
Advertisement
Advertisement
Back to Top