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10 October 2020 Chip-based wide-field 3D nanoscopy through tunable spatial-frequency-shift effect
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Abstract
Linear super-resolution microscopy via synthesis aperture approach permits fast acquisition owing to its wide-field implementations. However, it has been limited in resolution because a spatial-frequency band missing occurs when trying to use a shift magnitude surpassing the cutoff frequency of the detection system beyond a factor of two, which distorts the image severely. Here, we propose a method of chip-based 3D nanoscopy through a tunable spatial-frequency-shift effect capable of covering the full extent of the spatial-frequency component within a wide passband. The missing of the spatial spectrum can be effectively solved by developing a spatial-frequency-shift active tuning approach through wave vector manipulation and operation of optical modes propagating along multiple azimuthal directions on a waveguide chip. Besides, the method includes a chip-based sectioning capability, which is enabled by the saturated absorption of fluorophores.
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Mingwei Tang, Xiaowei Liu, Qing Yang, and Xu Liu "Chip-based wide-field 3D nanoscopy through tunable spatial-frequency-shift effect", Proc. SPIE 11549, Advanced Optical Imaging Technologies III, 115490L (10 October 2020); https://doi.org/10.1117/12.2575355
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