Laser immunotherapy for metastatic pancreatic cancer

Feifan Zhou

doi:10.1117/12.2575415

10 October 2020 Laser immunotherapy for metastatic pancreatic cancer

Feifan Zhou

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 115530Q (2020) https://doi.org/10.1117/12.2575415
Event: SPIE/COS Photonics Asia, 2020, Online Only

Abstract

Pancreatic cancer is an extremely malignant disease with high mortality rate. Currently there is no effective therapeutic strategy for highly metastatic pancreatic cancers. Laser immunotherapy (LIT) is a combination therapeutic approach of targeted phototherapy and immunotherapy, which could destroy treated primary tumors with elimination of untreated metastases. Here, we investigate the antitumor immune response of LIT on a highly aggressive phenotype Pnac02-H7 mouse pancreatic tumor model. LIT affords a remarkable efficacy in suppressing tumor growth in pancreatic tumors in mice, and results in complete tumor regression in many cases. LIT could synergize targeted phototherapy and immunological effects of immunoadjuvant, which represent a promising treatment modality to induce systemic antitumor response through a local intervention, paving the way for the treatment of highly metastatic pancreatic cancers.

Conference Presentation

Citation Download Citation

Feifan Zhou "Laser immunotherapy for metastatic pancreatic cancer", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 115530Q (10 October 2020); https://doi.org/10.1117/12.2575415

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