Diminution of melanin influence on the level of skin autofluorescence utilized for the estimation of advanced glycation end products level using green LED

Vladimir N. Grishanov; Dmitriy V. Kornilin

doi:10.1117/12.2581899

10 October 2020 Diminution of melanin influence on the level of skin autofluorescence utilized for the estimation of advanced glycation end products level using green LED

Vladimir N. Grishanov, Dmitriy V. Kornilin

Author Affiliations +

Proceedings Volume 11553, Optics in Health Care and Biomedical Optics X; 1155330 (2020) https://doi.org/10.1117/12.2581899
Event: SPIE/COS Photonics Asia, 2020, Online Only

Conference Poster

Abstract

The diagnostic potential of advanced glycation end products (AGE) estimation by its autofluorescence is restricted by not sufficient specificity and high level of variability even in case of the same individual. One of the reasons for this restriction is melanin influence on the signal measured by diagnostic fluorescence meter, as melanin is a strong endogenous chromophore. In addition, the AGE autofluorescence is excited by ultraviolet or violet radiation, the penetration depth of which into the skin is small. In order to decrease such influence, the green LED with a peak wavelength of 530 nm was implemented. The ratio of the fluorescent radiation intensity to the product of the two intensities of the elastically scattered skin radiation was used. One of them was scattering of ultraviolet LED light with a peak wavelength of 365 nm that excited autofluorescence, the other was green LED light. This approach results in two times lower melanin influence on AGE autofluorescence.

Citation Download Citation

Vladimir N. Grishanov and Dmitriy V. Kornilin "Diminution of melanin influence on the level of skin autofluorescence utilized for the estimation of advanced glycation end products level using green LED", Proc. SPIE 11553, Optics in Health Care and Biomedical Optics X, 1155330 (10 October 2020); https://doi.org/10.1117/12.2581899

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available