Broadband photoacoustic microscopy enhanced by surface plasmon resonance sensing

Changjun Min

doi:10.1117/12.2575170

10 October 2020 Broadband photoacoustic microscopy enhanced by surface plasmon resonance sensing

Changjun Min

Proceedings Volume 11557, Plasmonics V; 115570W (2020) https://doi.org/10.1117/12.2575170
Event: SPIE/COS Photonics Asia, 2020, Online Only

Abstract

Conventional optical-resolution photoacoustic microscopy is limited by poor axial imaging resolution because of insufficient ultrasound detection bandwidth. Here we propose a polarization-differential surface plasmon sensor for photoacoustic detection, and realized an enhanced noise-equivalent-pressure sensitivity of ~120 Pa and a much broader photoacoustic bandwidth over 200 MHz, which provides an axial resolution of ~6.5 µm. We demonstrated that the capability in such micrometer-scale resolution enables in vivo volumetric label-free imaging of the microvasculature in not only the thin ear but also the thick forelimb of living mice. With advantages of reflection-mode signal capture, improved photoacoustic detection sensitivity and bandwidth, our system offers more opportunities for biomedical investigation.

Conference Presentation

Citation Download Citation

Changjun Min "Broadband photoacoustic microscopy enhanced by surface plasmon resonance sensing", Proc. SPIE 11557, Plasmonics V, 115570W (10 October 2020); https://doi.org/10.1117/12.2575170

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