Diagnosis of blast-induced traumatic brain injury in rat based on terahertz spectroscopy of serum

Yuye Wang; Guoqiang Wang; Degang Xu; Bozhou Jiang; Meilan Ge; Limin Wu; Chuanyan Yang; Ning Mu; Shi Wang; Tunan Chen; Chao Chang; Hua Feng; Jianquan Yao

doi:10.1117/12.2575630

10 October 2020 Diagnosis of blast-induced traumatic brain injury in rat based on terahertz spectroscopy of serum

Yuye Wang, Guoqiang Wang, Degang Xu, Bozhou Jiang, Meilan Ge, Limin Wu, Chuanyan Yang, Ning Mu, Shi Wang, Tunan Chen, Chao Chang, Hua Feng, Jianquan Yao

Author Affiliations +

Proceedings Volume 11559, Infrared, Millimeter-Wave, and Terahertz Technologies VII; 1155919 (2020) https://doi.org/10.1117/12.2575630
Event: SPIE/COS Photonics Asia, 2020, Online Only

Conference Poster

Abstract

In this paper, a novel strategy for diagnosis of bTBI is proposed by measuring terahertz (THz) spectroscopy of serum in a rat model. A compressed air-driven shock wave generator was used to establish bTBI model of rats. It was validated by a neurological deficit assessment method. The spectral differences of serum for different degrees of bTBI rats have been demonstrated by THz time-domain spectroscopy (THz-TDS). Moreover, based on the THz spectra of serum, the principal component analysis (PCA) and support vector machine (SVM) were performed to automatically identify the degrees of bTBI. The results indicate that THz spectroscopy could provide a sensitive, rapid and label-free diagnosis method for bTBI.

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Citation Download Citation

Yuye Wang, Guoqiang Wang, Degang Xu, Bozhou Jiang, Meilan Ge, Limin Wu, Chuanyan Yang, Ning Mu, Shi Wang, Tunan Chen, Chao Chang, Hua Feng, and Jianquan Yao "Diagnosis of blast-induced traumatic brain injury in rat based on terahertz spectroscopy of serum", Proc. SPIE 11559, Infrared, Millimeter-Wave, and Terahertz Technologies VII, 1155919 (10 October 2020); https://doi.org/10.1117/12.2575630

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