Assessment of system performance and phantom validation of ultrasound-guided breast biopsy under dedicated positron emission mammography localization

Claire K. Park; Jeffrey Bax; Annabelle Pundaky; Lori Gardi; Aaron Fenster

doi:10.1117/12.2580590

15 February 2021 Assessment of system performance and phantom validation of ultrasound-guided breast biopsy under dedicated positron emission mammography localization

Claire K. Park, Jeffrey Bax, Annabelle Pundaky, Lori Gardi, Aaron Fenster

Author Affiliations +

Proceedings Volume 11598, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling; 115980H (2021) https://doi.org/10.1117/12.2580590
Event: SPIE Medical Imaging, 2021, Online Only

Abstract

The definitive diagnosis of breast cancer still requires obtaining a tissue sample, most commonly with an image-guided needle biopsy. High-resolution breast-dedicated positron emission mammography (PEM) has been used to guide biopsy due to its high sensitivity, specificity, and positive predictive value in detecting lesions. Although few promising methods have been proposed, these approaches require iterative procedures to verify three-dimensional (3D) needle positioning and anatomical context are not yet available. To address these challenges, we previously developed a mechatronic guidance system integrating an ultrasound (US)-guided core-needle biopsy (CNB) intervention to operate with a high-resolution PEM system. This paper presents the first assessment of system performance and phantom validation for PEM-US-guided biopsy under high-resolution PEM localization. We optimized the user interface by implementing a dynamic visualization module for 3D guidance within a simulated PEM image. Breast phantoms with targets in known 3D positions were fabricated, simulating PEM localized breast lesions and corresponding to virtual targets in the PEM image. The mechatronic guidance system was registered to the simulated PEM detector plate and real-time targeting was performed in three spatial dimensions. Biopsy procedures (N=8) were 100% successful in targets 6 mm diameter and height with a mean 3D positioning error <1.0 mm, and 0.72 mm in-plane and 0.34 mm cross-plane component errors, relative to the PEM image coordinate space. This first proof-of-concept study demonstrates a highly accurate system and feasible workflow toward PEM-USguided biopsy under high-resolution PEM localization

Conference Presentation

Citation Download Citation

Claire K. Park, Jeffrey Bax, Annabelle Pundaky, Lori Gardi, and Aaron Fenster "Assessment of system performance and phantom validation of ultrasound-guided breast biopsy under dedicated positron emission mammography localization", Proc. SPIE 11598, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling, 115980H (15 February 2021); https://doi.org/10.1117/12.2580590

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available