Approximate explicit feature map for computational augmentation of RGB images of hematoxylin and eosin stained histopathological specimens

Ivica Kopriva; Dario Sitnik; Gorana Aralica; Arijana Pačić; Marijana Popović Hadžija; Mirko Hadžija

doi:10.1117/12.2579408

15 February 2021 Approximate explicit feature map for computational augmentation of RGB images of hematoxylin and eosin stained histopathological specimens

Ivica Kopriva, Dario Sitnik, Gorana Aralica, Arijana Pačić, Marijana Popović Hadžija, Mirko Hadžija

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Proceedings Volume 11603, Medical Imaging 2021: Digital Pathology; 116030R (2021) https://doi.org/10.1117/12.2579408
Event: SPIE Medical Imaging, 2021, Online Only

Abstract

Hyperspectral imaging (HSI) is demonstrating the growing capability for disease diagnosis and surgical cancer resection. That is mainly due to high spectral resolution of HSI when compared with its color (RGB) counterparts. However, increased spectral resolution is often associated with the loss of spatial resolution. That combined with high cost hinders applicability of HSI. Herein, we propose computational approach that attempts to mimic the HSI. It is using an approximate explicit feature map (aEFM) to augment raw and/or stain normalized RGB images of the hematoxylin and eosin stained histopathological specimen. We demonstrate on two public labeled datasets, related to breast cancer and nuclei, the statistically significant improvement of performance of binary (caner vs. non-cancer) segmentation of augmented RGB images in comparison with the results achieved on their RGB counterparts. For the breast cancer, balanced accuracy is increased from 76.56%±9.05% to 80.42%±9.23% and F1 score from 13.34%±6.46% to 17.33%±6.36%. For nuclei, balanced accuracy is increased from 68.68%±9.25% to 79.99%±8.77% and F1 score from 46.92%±15.10% to 63.31%±14.50%. While  0 constrained nonnegative matrix factorization was used for binary segmentation herein, we conjecture that aEFM based augmentation of RGB images can improve performance of more sophisticated segmentation methods such as deep networks.

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Ivica Kopriva, Dario Sitnik, Gorana Aralica, Arijana Pačić, Marijana Popović Hadžija, and Mirko Hadžija "Approximate explicit feature map for computational augmentation of RGB images of hematoxylin and eosin stained histopathological specimens", Proc. SPIE 11603, Medical Imaging 2021: Digital Pathology, 116030R (15 February 2021); https://doi.org/10.1117/12.2579408

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