Subcutaneous injection of ICG for fractional thermal injury using an 808nm wide-area scanning laser diode

Haley L. Marks; Weeranut Phothong M.D.; Joshua Glahn; Tuanlian Luo; Garuna Kositratna; Dieter Manstein

doi:10.1117/12.2578754

5 March 2021 Subcutaneous injection of ICG for fractional thermal injury using an 808nm wide-area scanning laser diode

Haley L. Marks, Weeranut Phothong M.D., Joshua Glahn, Tuanlian Luo, Garuna Kositratna, Dieter Manstein

Proceedings Volume 11618, Photonics in Dermatology and Plastic Surgery 2021; 1161808 (2021) https://doi.org/10.1117/12.2578754
Event: SPIE BiOS, 2021, Online Only

Abstract

Non-fractional lasers used for hair removal penetrate deep into the tissue (~4 mm), and can be repurposed for enhanced thermal delivery using topically applied indocyanine green (ICG), a highly absorptive NIR dye. We demonstrate a new methodology for achieving fractional damage with an 808nm diode laser using a microneedle array injector and ICG impregnated PLGA nanoparticle formulation. A comparison of the effects of injection depth and irradiation dose between free ICG and PLGA@ICG revealed that the nanoparticle formulation effectively concentrates and confines the fluorophore locally at depths of ~3mm and thermal damage is achieved with irradiances as low as 10J/cm2. These improvements in the delivery of ICG subcutaneously in a fractional pattern allow for confined dermal tissue injury using low irradiances, minimizing discoloration of superficial layers of the skin, and significantly enhancing the depth of thermal injury achievable with a wide-area non-fractional laser diode.

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Haley L. Marks, Weeranut Phothong M.D., Joshua Glahn, Tuanlian Luo, Garuna Kositratna, and Dieter Manstein "Subcutaneous injection of ICG for fractional thermal injury using an 808nm wide-area scanning laser diode", Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 1161808 (5 March 2021); https://doi.org/10.1117/12.2578754

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KEYWORDS

Injuries

Indocyanine green

Laser therapeutics

Diodes

Skin

Erbium lasers

Laser tissue interaction

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