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5 March 2021 Correlation of ex-vivo focal laser ablation treatment of human prostate and porcine liver with MR imaging and histopathology: understanding the ablation zone
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Abstract
Transperineal laser ablation (TPLA) treatment of prostate cancer allows for a minimal invasive treatment approach. However, understanding of the ablation zone development and the 3D size are crucial for accurate treatment of prostate cancer. Therefore, we developed an ex-vivo experimental focal laser ablation set-up using a 1064nm CW diode laser to simulate a TPLA treatment, using human prostate and porcine liver. We quantitatively evaluated the thermal distribution and ablation zone volume on high-resolution MR imaging and histopathology to determine the 3D size of the ablation zone. These results allow for development of a dosimetry model of clinical TPLA treatments.
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© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Luigi A. van Riel M.D., Rob van Kollenburg M.D., Jorg Oddens M.D., Theo de Reijke M.D., Ton van Leeuwen, and Martijn de Bruin "Correlation of ex-vivo focal laser ablation treatment of human prostate and porcine liver with MR imaging and histopathology: understanding the ablation zone", Proc. SPIE 11619, Advanced Photonics in Urology, 1161904 (5 March 2021); https://doi.org/10.1117/12.2580353
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