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5 March 2021 Simulation of clinical focal laser ablation treatments to create a dosimetry model of the ablation zone using critical CEM43 values
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Abstract
Transperineal laser ablation (TPLA) treatment of prostate cancer allows for a minimal invasive treatment approach. However, a predictive dosimetry model for accurate treatment planning for prostate cancer is not yet available. Therefore, we simulated TPLA treatments on porcine liver and quantitatively evaluated thermal distribution and histology slides were made. Hereby, we determined the cumulative equivalent thermal isoeffect dose at 43°C (CEM43) that predicts cell death and led to the development of a dosimetry model.
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© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Luigi A. van Riel M.D., Rob A. van Kollenburg M.D., Remko Zweije, Hans Crezee, Theo M. de Reijke M.D., Jorg R. Oddens M.D., Ton G. van Leeuwen, and Martijn de Bruin "Simulation of clinical focal laser ablation treatments to create a dosimetry model of the ablation zone using critical CEM43 values", Proc. SPIE 11619, Advanced Photonics in Urology, 1161906 (5 March 2021); https://doi.org/10.1117/12.2582697
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