In-vivo analysis of acute chlorine gas inhalation injury using optical coherence tomography (OCT) in rabbit model

Zhikai Zhu; Yusi Miao; George Philipopoulos; Melody Doosty; Wenqi He; Jianing Tang; Jangwoen Lee; David Mukai; Fengyi Zhang; Saijun Qiu; Jing Cao; Xiao Gao; Sari Mahon; Livia Veress; Matthew Brenner; Carl White; Zhongping Chen

doi:10.1117/12.2577927

5 March 2021 In-vivo analysis of acute chlorine gas inhalation injury using optical coherence tomography (OCT) in rabbit model

Zhikai Zhu, Yusi Miao, George Philipopoulos, Melody Doosty, Wenqi He, Jianing Tang, Jangwoen Lee, David Mukai, Fengyi Zhang, Saijun Qiu, Jing Cao, Xiao Gao, Sari Mahon, Livia Veress, Matthew Brenner, Carl White, Zhongping Chen

Author Affiliations +

Proceedings Volume 11620, Endoscopic Microscopy XVI; 1162007 (2021) https://doi.org/10.1117/12.2577927
Event: SPIE BiOS, 2021, Online Only

Abstract

In this work, we demonstrate the ability to image and quantify airway changes, edema, and epithelial layer separation using OCT and automated tissue boundary identification in the rabbit large airways as early as 30-minutes post-chlorine gas exposure. We propose this novel approach will enable further investigations into using OCT for pre-hospital and point-of-care diagnostics of large airway injury due to airway toxic chemical exposure. With enhanced portability over conventional bronchoscopy, we believe our system is capable of field hospital deployment and investigating airway conditions in warfighters. Combining OCT with bronchoscopy would enhance the assessment and treatment of large airway chemical injury.

Conference Presentation

Citation Download Citation

Zhikai Zhu, Yusi Miao, George Philipopoulos, Melody Doosty, Wenqi He, Jianing Tang, Jangwoen Lee, David Mukai, Fengyi Zhang, Saijun Qiu, Jing Cao, Xiao Gao, Sari Mahon, Livia Veress, Matthew Brenner, Carl White, and Zhongping Chen "In-vivo analysis of acute chlorine gas inhalation injury using optical coherence tomography (OCT) in rabbit model", Proc. SPIE 11620, Endoscopic Microscopy XVI, 1162007 (5 March 2021); https://doi.org/10.1117/12.2577927

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Injuries

Chlorine gas

In vivo imaging

Imaging systems

Tissues

Bronchoscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years