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Adaptive optics optical coherence tomography technology enables non-invasive high-resolution retinal imaging and promises earlier detection of ocular disease. However, the images are corrupted by eye-movement artifacts that must be corrected to permit proper image analysis. We developed a method for efficiently removing eye-movement artifacts of A-lines using a multiple-reference global coordinate system. It corrects 3D translational eye movements, torsional eye movements, and image scaling, minimizing image distortion and substantially improving both regularity of the cone photoreceptor mosaic and clarity of individual cones.
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Kazuhiro Kurokawa, James A. Crowell, Nhan H. Do, John J. Lee, Donald T. Miller, "Multiple-reference global registration in adaptive optics OCT retina images," Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230A (5 March 2021); https://doi.org/10.1117/12.2578886