Choroidal differences in intensity, polarization, and spectral metrics observed longitudinally in the eyes of SOD1 mice

Conrad W. Merkle; Marco Augustin; Danielle J. Harper; Bernhard Baumann

doi:10.1117/12.2577651

5 March 2021 Choroidal differences in intensity, polarization, and spectral metrics observed longitudinally in the eyes of SOD1 mice

Conrad W. Merkle, Marco Augustin, Danielle J. Harper, Bernhard Baumann

Author Affiliations +

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230L (2021) https://doi.org/10.1117/12.2577651
Event: SPIE BiOS, 2021, Online Only

Abstract

Here we describe a new processing pipeline for assessing large amounts of OCT data and apply it to longitudinal imaging data from control and Superoxide Dismutase 1 knockout mice, a model for dry age related macular degeneration. We investigated average axial profiles and compared intensity, spectroscopic, and polarization metrics in the choroid. We found statistically significant differences between groups, suggesting pigmentation changes within the choroid. Analysis of axial profiles reduces the complexity and of analysis which may be valuable in a clinical setting for preventative care, where specific features are not necessarily expected, but trends may be observed over time.

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Citation Download Citation

Conrad W. Merkle, Marco Augustin, Danielle J. Harper, and Bernhard Baumann "Choroidal differences in intensity, polarization, and spectral metrics observed longitudinally in the eyes of SOD1 mice", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230L (5 March 2021); https://doi.org/10.1117/12.2577651

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