Radiation dosimetry in translational intrathecal imaging

Jacob Y. Hesterman; Paul Segars; Keryn Palmer; Howard Dobson; Susan Kost

doi:10.1117/12.2581867

5 March 2021 Radiation dosimetry in translational intrathecal imaging

Jacob Y. Hesterman, Paul Segars, Keryn Palmer, Howard Dobson, Susan Kost

Proceedings Volume 11624, Visualizing and Quantifying Drug Distribution in Tissue V; 1162406 (2021) https://doi.org/10.1117/12.2581867
Event: SPIE BiOS, 2021, Online Only

Abstract

Intrathecal (IT) administration is a drug delivery method with great potential for the treatment of a broad range of neurodegenerative disorders. Imaging is a useful tool for assessing the biodistribution of intrathecally administered molecules, especially for longer-lived radionuclides. However, longer-lived radionuclides are often associated with higher radiation absorbed dose, a quantitative measure computed from serial imaging data. We have developed a custom dosimetry model to support intrathecal administration. In this work, emphasis is placed on recent model refinements to improve absorbed dose estimates to the spinal cord and its implication for dosimetry calculation in translational imaging trials.

Conference Presentation

Citation Download Citation

Jacob Y. Hesterman, Paul Segars, Keryn Palmer, Howard Dobson, and Susan Kost "Radiation dosimetry in translational intrathecal imaging", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 1162406 (5 March 2021); https://doi.org/10.1117/12.2581867

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